Description

1. Product Overview: Xendox 400 is an injectable formulation of Doxorubicin Hydrochloride, a cytotoxic anticancer agent used in the treatment of a wide range of malignancies.

2. Composition: Active Ingredient: Doxorubicin Hydrochloride | Dosage Form: Injection

3. Pharmacological Class: Anthracycline Antibiotic

4. Mechanism of Action: Doxorubicin intercalates into DNA and inhibits topoisomerase II, disrupting DNA replication and transcription, leading to cancer cell death.

5. Indications: Breast cancer | Leukemia | Lymphoma | Sarcomas | Other solid tumors

6. Dosage & Administration: As prescribed by oncologist | Intravenous use | Dose depends on body surface area and clinical condition | Administered under medical supervision

7. Clinical Benefits: Broad-spectrum anticancer activity | Effective in multiple cancer types | Helps reduce tumor size | Used in combination chemotherapy regimens

8. Contraindications: Hypersensitivity to Doxorubicin or other anthracyclines | Severe cardiac impairment

9. Precautions: Monitor cardiac function (risk of cardiotoxicity) | Monitor blood counts regularly | Risk of severe myelosuppression | Use under specialist supervision

10. Drug Interactions: Concurrent use with other cardiotoxic or myelosuppressive agents may increase toxicity

11. Special Populations: Pregnancy contraindicated | Lactation not recommended | Pediatric use requires specialist advice | Use cautiously in hepatic impairment

12. Adverse Effects: Nausea | Vomiting | Hair loss (alopecia) | Myelosuppression | Cardiotoxicity

13. Storage Conditions: Store below 25°C | Protect from light | Do not freeze | Keep out of reach of children

14. Packaging: Injection vial

15. Manufacturer: Everest Pharmaceutical Ltd.