Description

1. Product Overview: Daprostat-2® is a hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor containing Daprodustat, used for the management of anemia in chronic kidney disease patients, especially in dialysis and non-dialysis cases as per clinical indication.

2. Composition: Daprodustat INN 2 mg | Dosage Form: Tablet

3. Pharmacological Class: HIF Prolyl Hydroxylase Inhibitor

4. Mechanism of Action: Daprodustat stabilizes hypoxia-inducible factor (HIF), leading to increased endogenous erythropoietin production, improved iron utilization, and stimulation of red blood cell production.

5. Indications: Anemia of chronic kidney disease (CKD) in dialysis and non-dialysis patients

6. Dosage & Administration: As directed by physician or nephrology specialist only | Oral use | Usually taken once daily | Dose adjusted based on hemoglobin response

7. Clinical Benefits: Increases hemoglobin levels | Reduces need for injectable erythropoietin | Improves anemia symptoms such as fatigue and weakness | Enhances quality of life in CKD patients

8. Contraindications: Hypersensitivity to Daprodustat or any component of the formulation

9. Precautions: Risk of thromboembolic events | Regular hemoglobin monitoring required | Use cautiously in patients with cardiovascular disease or cancer history

10. Drug Interactions: May interact with strong CYP enzyme modulators and iron supplements (timing adjustment may be required)

11. Special Populations: Use in pregnancy and lactation only if clearly necessary and prescribed | Elderly use under strict medical supervision

12. Adverse Effects: Headache | Nausea | Hypertension | Thrombotic events (rare) | Diarrhea

13. Storage Conditions: Store below 30°C | Protect from light and moisture | Keep out of reach of children

14. Packaging: Tablet blister pack

15. Manufacturer: Everest Pharmaceutical Ltd.