Description

1. Product Overview: Dotiric is a tablet formulation of Dotinurad INN 0.5 mg, a selective urate reabsorption inhibitor used in the management of hyperuricemia and gout.
2. Composition: Active Ingredient: Dotinurad INN 0.5 mg | Dosage Form: Tablet
3. Pharmacological Class: URAT1 (Urate Transporter 1) Inhibitor
4. Mechanism of Action: Dotinurad selectively inhibits URAT1 in the renal proximal tubules, reducing reabsorption of uric acid and increasing its excretion in urine, thereby lowering serum uric acid levels.
5. Indications: Hyperuricemia | Gout (including prevention of gout flares)
6. Dosage & Administration: As prescribed by physician | Oral use | Usually once daily after meals | Dose titration may be required
7. Clinical Benefits: Effectively lowers serum uric acid | Reduces frequency of gout attacks | Well tolerated for long-term management
8. Contraindications: Hypersensitivity to Dotinurad or any component
9. Precautions: Maintain adequate hydration | Monitor uric acid levels regularly | Use cautiously in renal impairment
10. Drug Interactions: May interact with other uricosuric agents and drugs affecting renal function
11. Special Populations: Pregnancy: Use only if necessary | Lactation: Consult physician | Dose adjustment may be required in renal impairment
12. Adverse Effects: Increased urination | Joint pain (initial gout flare) | Mild gastrointestinal discomfort
13. Storage Conditions: Store below 30°C | Protect from light and moisture | Keep out of reach of children
14. Packaging: Tablet in blister pack
15. Manufacturer: Everest Pharmaceutical Ltd.