{"id":271,"date":"2026-04-24T19:32:06","date_gmt":"2026-04-24T19:32:06","guid":{"rendered":"https:\/\/asceticit.shop\/wp2\/?post_type=product&p=271"},"modified":"2026-04-26T16:26:30","modified_gmt":"2026-04-26T16:26:30","slug":"pemrest","status":"publish","type":"product","link":"https:\/\/asceticit.shop\/wp2\/product\/pemrest\/","title":{"rendered":"Pemrest"},"content":{"rendered":"

1. Product Overview:<\/strong>
Pemrest\u00ae is an injectable formulation of Pemetrexed Disodium, an antifolate chemotherapeutic agent used in the treatment of malignant pleural mesothelioma and non-small cell lung cancer (NSCLC).<\/p>\n

2. Composition:<\/strong>
Active Ingredient: Pemetrexed Disodium | Dosage Form: Injection (Lyophilized Powder)<\/p>\n

3. Pharmacological Class:<\/strong>
Antifolate Antineoplastic Agent<\/p>\n

4. Mechanism of Action:<\/strong>
Pemetrexed inhibits multiple folate-dependent enzymes involved in purine and pyrimidine synthesis, leading to inhibition of DNA and RNA synthesis and ultimately cancer cell death.<\/p>\n

5. Indications:<\/strong>
Non-small cell lung cancer (NSCLC) | Malignant pleural mesothelioma | Maintenance therapy in advanced lung cancer<\/p>\n

6. Dosage & Administration:<\/strong>
As prescribed by oncologist | Intravenous infusion only | Administered in combination with other chemotherapy agents | Dose based on body surface area<\/p>\n

7. Clinical Benefits:<\/strong>
Slows tumor growth | Improves survival in NSCLC and mesothelioma | Effective in combination therapy regimens | Reduces cancer progression<\/p>\n

8. Contraindications:<\/strong>
Hypersensitivity to Pemetrexed or any component | Severe renal impairment<\/p>\n

9. Precautions:<\/strong>
Monitor blood counts regularly | Risk of myelosuppression | Renal function monitoring required | Folic acid and vitamin B12 supplementation required during therapy | Use under specialist supervision<\/p>\n

10. Drug Interactions:<\/strong>
NSAIDs and nephrotoxic drugs may increase toxicity risk | Interactions with other chemotherapeutic agents possible<\/p>\n

11. Special Populations:<\/strong>
Pregnancy: Contraindicated | Lactation: Not recommended | Pediatric: Safety not established | Elderly: Requires careful dose adjustment<\/p>\n

12. Adverse Effects:<\/strong>
Fatigue | Nausea | Vomiting | Anemia | Neutropenia | Rash | Elevated liver enzymes<\/p>\n

13. Storage Conditions:<\/strong>
Store below 25\u00b0C | Protect from light and moisture | Reconstituted solution to be used as directed | Keep out of reach of children<\/p>\n

14. Packaging:<\/strong>
Vial (Injection powder for reconstitution)<\/p>\n

15. Manufacturer:<\/strong>
Everest Pharmaceutical Ltd.<\/p>\n","protected":false},"excerpt":{"rendered":"

Generic Name:<\/strong> Pemetrexed Disodium
Strength:<\/strong> 500 mg (as available)
Dosage Form:<\/strong> Injection (Lyophilized Powder)
Category:<\/strong> Anticancer Chemotherapy
TG Name:<\/strong> Antifolate Agent
Status:<\/strong> Prescription Only Medicine<\/p>\n

\n

Short Description<\/strong><\/span><\/h2>\n

Pemrest\u00ae is an anticancer injection containing Pemetrexed Disodium, used for the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma. It works by blocking folate-dependent metabolic processes essential for cancer cell growth and replication. To be used under oncology supervision.<\/p>\n","protected":false},"featured_media":360,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[23,30],"product_tag":[],"class_list":{"0":"post-271","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-general-products","7":"product_cat-immunomodulators","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product\/271","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/comments?post=271"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/media\/360"}],"wp:attachment":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/media?parent=271"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_brand?post=271"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_cat?post=271"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_tag?post=271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}