{"id":150,"date":"2026-04-14T17:23:45","date_gmt":"2026-04-14T17:23:45","guid":{"rendered":"https:\/\/asceticit.shop\/wp2\/?post_type=product&#038;p=150"},"modified":"2026-04-25T18:33:42","modified_gmt":"2026-04-25T18:33:42","slug":"ponaxen-15","status":"publish","type":"product","link":"https:\/\/asceticit.shop\/wp2\/product\/ponaxen-15\/","title":{"rendered":"Ponaxen 15"},"content":{"rendered":"<p><strong>1. Product Overview:<\/strong> Ponaxen 15 is a potent targeted anticancer formulation of Ponatinib Hydrochloride INN 15 mg, designed for the treatment of specific types of chronic myeloid leukemia and acute lymphoblastic leukemia.<br \/>\n<strong>2. Composition:<\/strong> Active Ingredient: Ponatinib Hydrochloride INN 15 mg | Dosage Form: Tablet<br \/>\n<strong>3. Pharmacological Class:<\/strong> Tyrosine Kinase Inhibitor (TKI) | Pan-BCR-ABL Inhibitor<br \/>\n<strong>4. Mechanism of Action:<\/strong> Ponatinib inhibits the BCR-ABL tyrosine kinase, including the T315I mutation, which is resistant to other TKIs. It blocks the signaling pathways that drive the overproduction of abnormal white blood cells.<br \/>\n<strong>5. Indications:<\/strong> Chronic Myeloid Leukemia (CML) | Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) | T315I-positive CML or Ph+ ALL<br \/>\n<strong>6. Dosage &#038; Administration:<\/strong> As prescribed by oncologist | Oral use | May be taken with or without food | Swallow tablets whole<br \/>\n<strong>7. Clinical Benefits:<\/strong> Effective against T315I mutation-positive leukemia | Targeted therapy approach | Delays disease progression | Oral dosing convenience<br \/>\n<strong>8. Contraindications:<\/strong> Hypersensitivity to Ponatinib or any component<br \/>\n<strong>9. Precautions:<\/strong> Monitor for arterial occlusion and thromboembolism | Risk of hepatotoxicity and heart failure | Monitor for hypertension and pancreatitis | Regular blood counts required<br \/>\n<strong>10. Drug Interactions:<\/strong> Strong CYP3A inhibitors may increase drug levels | Gastric acid-reducing agents may decrease absorption<br \/>\n<strong>11. Special Populations:<\/strong> Pregnancy contraindicated due to fetal risk | Lactation not recommended | Use with caution in patients with pre-existing cardiovascular risk<br \/>\n<strong>12. Adverse Effects:<\/strong> Hypertension | Rash | Abdominal pain | Fatigue | Headache | Dry skin<br \/>\n<strong>13. Storage Conditions:<\/strong> Store below 30\u00b0C | Protect from light and moisture | Keep out of reach of children<br \/>\n<strong>14. Packaging:<\/strong> Tablet in blister pack<br \/>\n<strong>15. Manufacturer:<\/strong> Everest Pharmaceutical Ltd.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><strong>Ponaxen 15\u00ae<\/strong><br \/>\n<strong>Generic Name:<\/strong> Ponatinib Hydrochloride<br \/>\n<strong>Strength:<\/strong> 15 mg<br \/>\n<strong>Dosage Form:<\/strong> Tablet<br \/>\n<strong>Category:<\/strong> Targeted Anticancer Therapy<br \/>\n<strong>TG Name:<\/strong> BCR-ABL Inhibitor<br \/>\n<strong>Status:<\/strong> Prescription Only Medicine<\/p>\n<p><strong>1. What is Ponaxen 15\u00ae?<\/strong><br \/>\nPonaxen 15\u00ae is a tablet containing Ponatinib Hydrochloride INN 15 mg. It is used for the treatment of adult patients with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is specifically effective for patients who are resistant or intolerant to other kinase inhibitors. To be used as directed by a registered physician.<\/p>\n","protected":false},"featured_media":155,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[19,22],"product_tag":[],"class_list":{"0":"post-150","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-oncology","7":"product_cat-specialized-product","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/comments?post=150"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/media\/155"}],"wp:attachment":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/media?parent=150"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_brand?post=150"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_cat?post=150"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_tag?post=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}