{"id":149,"date":"2026-04-14T17:23:20","date_gmt":"2026-04-14T17:23:20","guid":{"rendered":"https:\/\/asceticit.shop\/wp2\/?post_type=product&p=149"},"modified":"2026-04-25T19:58:24","modified_gmt":"2026-04-25T19:58:24","slug":"ponaxen-45","status":"publish","type":"product","link":"https:\/\/asceticit.shop\/wp2\/product\/ponaxen-45\/","title":{"rendered":"Ponaxen 45"},"content":{"rendered":"
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1. Product Overview:<\/strong> Ponaxen 45\u00ae is a third-generation tyrosine kinase inhibitor containing Ponatinib, used for the treatment of resistant or intolerant chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia.<\/p>\n

2. Composition:<\/strong> Ponatinib INN 45 mg | Dosage Form: Tablet<\/p>\n

3. Pharmacological Class:<\/strong> Tyrosine Kinase Inhibitor (BCR-ABL Inhibitor)<\/p>\n

4. Mechanism of Action:<\/strong> Ponatinib inhibits BCR-ABL tyrosine kinase, including T315I mutation variants, thereby blocking proliferation and survival of malignant hematopoietic cells.<\/p>\n

5. Indications:<\/strong> Chronic myeloid leukemia (CML) | Philadelphia chromosome\u2013positive acute lymphoblastic leukemia (Ph+ ALL) | Resistant or intolerant CML cases<\/p>\n

6. Dosage & Administration:<\/strong> As directed by oncology specialist only | Oral use | Once daily | Tablet should be swallowed whole with water<\/p>\n

7. Clinical Benefits:<\/strong> Controls resistant blood cancers | Inhibits abnormal cancer cell growth | Improves disease control in TKI-resistant cases | Supports long-term cancer management<\/p>\n

8. Contraindications:<\/strong> Hypersensitivity to Ponatinib or any component of the formulation<\/p>\n

9. Precautions:<\/strong> Risk of arterial thrombosis and cardiovascular events | Regular monitoring of blood pressure and cardiac status required | Use cautiously in patients with cardiovascular risk factors<\/p>\n

10. Drug Interactions:<\/strong> May interact with strong CYP3A inhibitors or inducers | Caution with anticoagulants and antihypertensive agents<\/p>\n

11. Special Populations:<\/strong> Not recommended during pregnancy and lactation unless clearly necessary | Elderly use under strict medical supervision<\/p>\n

12. Adverse Effects:<\/strong> Hypertension | Rash | Fatigue | Abdominal pain | Thrombosis risk | Liver enzyme elevation | Headache<\/p>\n

13. Storage Conditions:<\/strong> Store below 30\u00b0C | Protect from light and moisture | Keep out of reach of children<\/p>\n

14. Packaging:<\/strong> Tablet blister pack<\/p>\n

15. Manufacturer:<\/strong> Everest Pharmaceutical Ltd.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Generic Name:<\/strong> Ponatinib INN
Strength:<\/strong> 45 mg
Dosage Form:<\/strong> Tablet
Category:<\/strong> Antineoplastic \/ Tyrosine Kinase Inhibitor (TKI)
TG Name:<\/strong> Hematological Cancer Management
Status:<\/strong> Prescription Only Medicine (POM)<\/p>\n

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Short Description<\/h2>\n

Ponaxen 45\u00ae<\/strong> is a targeted anticancer medicine containing Ponatinib INN 45 mg, used for the treatment of certain blood cancers, including chronic myeloid leukemia (CML) and Philadelphia chromosome\u2013positive acute lymphoblastic leukemia (Ph+ ALL). It works by blocking abnormal cancer cell signaling. To be used only under specialist supervision.<\/p>\n","protected":false},"featured_media":154,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[19,22],"product_tag":[],"class_list":{"0":"post-149","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-oncology","7":"product_cat-specialized-product","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product\/149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/comments?post=149"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/media\/154"}],"wp:attachment":[{"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/media?parent=149"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_brand?post=149"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_cat?post=149"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/asceticit.shop\/wp2\/wp-json\/wp\/v2\/product_tag?post=149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}